We are EManiacs! We are developing innovative electron microscopy techniques and applying those techniques to study the cellular and molecular basis of synaptic transmission and plasticity. Three basic parameters control the synaptic
output: 1) the probability of synaptic release, 2) the number of synaptic vesicles available for exocytosis, and 3) the number of postsynaptic receptors and their alignment to fusion sites. We aim to elucidate how these parameters
are regulated at the ultrastructural level and how they are influenced by other cells such as astrocytes and microglia.
